Izumo1和Juno在哺乳动物受精过程中的研究进展

doi:10.11843/j.issn.0366-6964.2019.09.002

畜牧兽医学报 ›› 2019, Vol. 50 ›› Issue (9): 1737-1745.doi: 10.11843/j.issn.0366-6964.2019.09.002

Izumo1和Juno在哺乳动物受精过程中的研究进展

胡文萍¹, 汤继顺^1,2, 张壮彪¹, 喇永富¹, 刘秋月¹, 狄冉¹, 王翔宇¹, 储明星^1*

1. 中国农业科学院北京畜牧兽医研究所, 农业部动物遗传育种与繁殖重点实验室, 北京 100193;
2. 安徽省农业科学院畜牧兽医研究所, 合肥 230031

收稿日期:2019-02-28 出版日期:2019-09-23 发布日期:2019-09-23
通讯作者: 储明星,主要从事羊优异繁殖性状分子机理研究,E-mail:mxchu@263.net
作者简介:胡文萍(1985-),女,江西南昌人,博士,助理研究员,主要从事动物遗传育种研究,Tel:010-62816001,E-mail:huwenping@caas.cn;汤继顺(1979-),男,安徽合肥人,博士生,主要从事动物分子遗传学研究,E-mail:tjs157@163.com
基金资助:
国家自然科学基金（31501941；31861143012）；中央级公益性科研院所基本科研业务费专项（2018-YWF-YB-1；2015ywf-zd-2；Y2017JC24；2017ywf-zd-13）；国家肉羊产业技术体系专项（CARS-38）；中国农业科学院科技创新工程（ASTIP-IAS13）；农业科研杰出人才及其创新团队项目（农办人[2015]62号）；国家万人计划科技创新领军人才项目（W02020274）；天津市农业科技成果转化与推广项目（201704020）

Progress of Izumo1 and Juno in Mammalian Fertilization

HU Wenping¹, TANG Jishun^1,2, ZHANG Zhuangbiao¹, LA Yongfu¹, LIU Qiuyue¹, DI Ran¹, WANG Xiangyu¹, CHU Mingxing^1*

1. Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230031, China

Received:2019-02-28 Online:2019-09-23 Published:2019-09-23

摘要/Abstract

摘要： 受精是哺乳动物一个精确而且高度协调的生理过程。精子与卵子的融合是其中最关键的一步。两个高度分化的单倍体生殖细胞，精子和卵子，通过融合形成一个全新的受精卵，并发育为胚胎。Izumo1和Juno是目前发现的第一个精子和卵子质膜上的配体-受体蛋白对，它们的相互作用是精卵识别所必须的。本文综述了这两种重要蛋白的发现及它们在精卵融合过程中的相互作用，同时阐述了哺乳动物受精过程的最新研究进展。

Abstract: Fertilization is a precise and highly coordinated physiological process in mammals. Sperm-egg fusion is the most critical step. Two highly differentiated haploid gametes, sperm and egg, fuse to form a new zygote, and develop into an embryo. Izumo1 and Juno were the first ligand-receptor proteins, which were found on the plasma membrane of sperm and egg. Their interaction is necessary for sperm-egg recognition. This paper reviews the discovery process of the two important proteins, their interaction during sperm-egg fusion and the latest research progress in mammalian fertilization.

中图分类号:

S814

胡文萍, 汤继顺, 张壮彪, 喇永富, 刘秋月, 狄冉, 王翔宇, 储明星. Izumo1和Juno在哺乳动物受精过程中的研究进展[J]. 畜牧兽医学报, 2019, 50(9): 1737-1745.

HU Wenping, TANG Jishun, ZHANG Zhuangbiao, LA Yongfu, LIU Qiuyue, DI Ran, WANG Xiangyu, CHU Mingxing. Progress of Izumo1 and Juno in Mammalian Fertilization[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(9): 1737-1745.

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Izumo1和Juno在哺乳动物受精过程中的研究进展

Progress of Izumo1 and Juno in Mammalian Fertilization

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